Endocrine Abstracts

NSAIDs inhibit cyclooxygenase activity and thereby reduce prostaglandin synthesis. Two genetic isoforms of COX have been characterized: COX 1 constituvely produced in most tissues and COX 2 is not expressed in most normal tissues which is induced by pro inflammatory and mitogenic stimuli. Chronic inflammation and oxidative stress are key players in COX2 dependent carcinogenesis and it is important to point out that this type of inflammation has been associated with cancer in d...

BackgroundCentral kisspeptin action is well known in reproductive regulation; however, its peripheral action is not well understood. Most studies reveal that kisspeptin signaling influences energy and metabolic status.ObjectiveTo compare serum kisspeptin levels 1) between adult patients with PWS, obese subjects matched for age, sex and BMI and healthy subjects; 2) in adult patients with PWS before and after t...